Physica Medica: European Journal of Medical Physics
Volume 22, Issue 1 , Pages 3-15 , January 2006

Effective beam directions using radiobiologically optimized IMRT of node positive breast cancer

  • Brigida Costa Ferreira

      Affiliations

    • Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Stockholm (Sweden)
    • Corresponding Author InformationAddress for correspondence: B. Costa Ferreira, Department of Medical Radiation Physics, Karolinska Institutet, PO Box 260, S-171 76 Stockholm, Sweden. Tel: +468 517 72776; Fax: +468 343525
    • ,
  • Roger Svensson

      Affiliations

    • Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Stockholm (Sweden)
    • ,
  • Bengt Lind

      Affiliations

    • Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Stockholm (Sweden)
    • ,
  • Jonas Johansson

      Affiliations

    • Section of Oncology, University of Uppsala, Akademiska sjukhuset, Uppsala (Sweden)
    • ,
  • Anders Brahme

      Affiliations

    • Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Stockholm (Sweden)

Received 7 October 2005 ,Revised 29 March 2006 ,Accepted 4 April 2006.

References 

  1. Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347(16):1233–1241
  2. Early Breast Cancer Trialists' Collaborative Group. Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: An overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group. Lancet. 2000;355:1757–1770
  3. Cuzick J, Stewart H, Rutqvist L, et al. Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy. J Clin Oncol. 1994;12(3):447–453
  4. Paszat LF, Mackillop WJ, Groome PA, et al. Mortality from myocardial infarction following postlumpectomy radiotherapy for breast cancer: a population-based study in Ontario, Canada. Int J Radiat Oncol Biol Phys. 1999;43(4):755–762
  5. Lind PA, Marks LB, Hardenbergh PH, et al. Technical factors associated with radiation pneumonitis after local +/− regional radiation therapy for breast cancer. Int J Radiat Oncol Biol Phys. 2002;52(1):137–143
  6. Powell SN, Alphonse G, Taghian AG, et al. Risk of lymphedema after regional nodal irradiation with breast conservation therapy. Int J Radiat Oncol Biol Phys. 2003;55(5):1209–1215
  7. Pierce SM, Recht A, Lingos TI, et al. Long-term radiation complications following conservative surgery (CS) and radiation therapy (RT) in patients with early stage breast cancer. Int J Radiat Oncol Biol Phys. 1992;23(5):915–923
  8. Rutqvist LE, Liedberg A, Hammar N, Dalberg K. Myocardial infarction among women with early-stage breast cancer treated with conservative surgery and breast irradiation. Int J Radiat Oncol Biol Phys. 1998;40(2):359–363
  9. Lievens Y, Poortmans P, Van den Bogaert W. A glance on quality assurance in EORTC study 22922 evaluating techniques for internal mammary and medial supraclavicular lymph node chain irradiation in breast cancer. Radiother Oncol. 2001;60(3):257–265
  10. Severin D, Connors S, Thompson H, et al. Breast radiotherapy with inclusion of internal mammary nodes: a comparison of techniques with three-dimensional planning. Int J Radiat Oncol Biol Phys. 2003;55(3):633–644
  11. Jansson T, Lindman H, Nygard K, et al. Radiotherapy of breast cancer after breast-conserving surgery: an improved technique using mixed electron-photon beams with a multileaf collimator. Radiother Oncol. 1998;46:83–98
  12. Lu XQ, Sullivan S, Eggleston T, et al. A three-field breast treatment technique with precise geometric matching using multileaf collimator-equipped linear accelerators. Int J Radiat Oncol Biol Phys. 2003;55(5):1420–1431
  13. Essers M, Eggen M, Binnekamp D, et al. Chest wall irradiation with MLC-shaped photon and electron fields. Int J Radiat Oncol Biol Phys. 2000;48(4):1205–1217
  14. Scrimger RA, Connors SG, Halls SB, Starreveld AA. CT-targeted irradiation of the breast and internal mammary lymph nodes using a 5-field technique. Int J Radiat Oncol Biol Phys. 2000;48(4):983–989
  15. Johansen J, Overgaard J, Rose C, et al. Danish Breast Cancer Cooperative Group (DBCG) and the DBCG Radiotherapy Committee. Cosmetic outcome and breast morbidity in breast-conserving treatment-results from the Danish DBCG-82TM national randomized trial in breast cancer. Acta Oncol. 2002;41(4):369–380
  16. Vrieling C, Collette L, Fourquet A, et al. The influence of patient, tumor and treatment factors on the cosmetic results after breast-conserving therapy in the EORTC ‘boost vs. no boost’ trial. EORTC Radiotherapy and Breast Cancer Cooperative Groups. Radiother Oncol. 2000;55(3):219–232
  17. Neal AJ, Torr M, Helyer S, Yarnold JR. Correlation of breast dose heterogeneity with breast size using 3D CT planning and dose-volume histograms. Radiother Oncol. 1995;34(3):210–218
  18. Evans PM, Donovan EM, Fenton N, et al. Practical implementation of compensators in breast radiotherapy. Radiother Oncol. 1998;49(3):255–265
  19. Brooks PS. Dose to contralateral breast-a comparative study. Med Dosim. 1995;20(4):301–307
  20. Hurkmans CW, Borger JH, Bos LJ, et al. Cardiac and lung complication probabilities after breast cancer irradiation. Radiother Oncol. 2000;55(2):145–151
  21. Skoczylas JZ, Bentzen SM, Overgaard M, Overgaard J. Time course of radiological lung density changes after postmastectomy radiotherapy. Acta Oncol. 2000;39(2):181–187
  22. Nixon AJ, Manola J, Gelman R, et al. No long-term increase in cardiac-related mortality after breast-conserving surgery and radiation therapy using modern techniques. J Clin Oncol. 1998;16(4):1374–1379
  23. Vallis KA, Pintilie M, Chong N, et al. Assessment of coronary heart disease morbidity and mortality after radiation therapy for early breast cancer. J Clin Oncol. 2002;20(4):1036–1042
  24. Gagliardi G, Lax I, Soderstrom S, et al. Prediction of excess risk of long-term cardiac mortality after radiotherapy of stage I breast cancer. Radiother Oncol. 1998;46(1):63–71
  25. Overgaard M, Jensen MB, Overgaard J, et al. Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Lancet. 1999;353(9165):1641–1648
  26. Shapiro CL, Hardenbergh PH, Gelman R, et al. Cardiac effects of adjuvant doxorubicin and radiation therapy in breast cancer patients. J Clin Oncol. 1998;16(11):3493–3501
  27. Blomqvist C, Tiusanen K, Elomaa I, et al. The combination of radiotherapy, adjuvant chemotherapy (cyclophosphamide-doxorubicin-ftorafur) and tamoxifen in stage II breast cancer. Long-term follow-up results of a randomised trial. Br J Cancer. 1992;66(6):1171–1176
  28. Fiets WE, van Helvoirt RP, Nortier JW, et al. Acute toxicity of concurrent adjuvant radiotherapy and chemotherapy (CMF or AC) in breast cancer patients. a prospective, comparative, non-randomised study. Eur J Cancer. 2003;39(8):1081–1088
  29. Johansson S, Löfroth PO, Denekamp J. Left sided vocal cord paralysis: a newly recognized late complication of mediastinal irradiation. Radiother Oncol. 2001;58(3):287–294
  30. Cho BC, Hurkmans CW, Damen EM, et al. Intensity modulated versus non-intensity modulated radiotherapy in the treatment of the left breast and upper internal mammary lymph node chain: a comparative planning study. Radiother Oncol. 2002;62(2):127–136
  31. Krueger EA, Fraass BA, Pierce LJ. Clinical aspects of intensity-modulated radiotherapy in the treatment of breast cancer. Semin Radiat Oncol. 2002;12(3):250–259
  32. sell M, Hyodynmaa S, Gustafsson A, Brahme A. Optimization of 3D conformal electron beam therapy in inhomogeneous media by concomitant fluence and energy modulation. Phys Med Biol. 1997;42(11):2083–2100
  33. Korevaar EW, Huizenga H, Lof J, et al. Investigation of the added value of high-energy electrons in intensity-modulated radiotherapy: four clinical cases. Int J Radiat Oncol Biol Phys. 2002;52(1):236–253
  34. Fogliata A, Bolsi A, Cozzi L. Critical appraisal of treatment techniques based on conventional photon beams, intensity modulated photon beams and proton beams for therapy of intact breast. Radiother Oncol. 2002;62(2):137–145
  35. Vicini FA, Sharpe M, Kestin L, et al. Optimizing breast cancer treatment efficacy with intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys. 2002;54(5):1336–1344
  36. Smitt MC, Li SD, Shostak CA, et al. Breast-conserving radiation therapy: Potential of inverse planning with intensity modulation. Radiology. 1997;203:871–876
  37. Landau D, Adams EJ, Webb S, Ross G. Cardiac avoidance in breast radiotherapy: a comparison of simple shielding techniques with intensity-modulated radiotherapy. Radiother Oncol. 2001;60(3):247–255
  38. Thilmann C, Zabel A, Milker-Zabel S, et al. Number and Orientation of Beams in Inversely Planned Intensity-Modulated Radiotherapy of the Female Breast and the Parasternal Lymph Nodes. Am J Clin Oncol. 2003;26(5):E136–E143
  39. Löf J. Development of a general framework for optimization of radiation therapy. In: Ph.D. Thesis. Sweden: Stockholm University; 2000;
  40. Söderström S, Gustafsson A, Brahme A. The clinical value of different treatment objectives and degrees of freedom in radiation therapy optimization. Radiother Oncol. 1993;29(2):148–163
  41. sell M, Hyodynmaa S, Soderstrom S, Brahme A. Optimal electron and combined electron and photon therapy in the phase space of complication-free cure. Phys Med Biol. 1999;44(1):235–252
  42. Johansson J, Isacsson U, Lindman H, et al. Node-positive left-sided breast cancer patients after breast-conserving surgery: potential outcomes of radiotherapy modalities and techniques. Radiother Oncol. 2002;65(2):89–98
  43. Aaltonen P, Brahme A, Lax I, et al. Specification of dose delivery in radiation therapy, Recommendations by the NACP. Acta Oncol. 1997;36(Suppl. 10):1–32
  44. ICRU . In: Report 62: Prescribing, recording and reporting photon beam therapy (supplement to ICRU report 50). Bethesda: International Commission on Radiation Units and Measurements; 1999;
  45. Gaghandi G, Lax I, Ottolenghi A, Rutqvist LE. Long-term cardiac mortality after radiotherapy of breast cancer-application of the relative seriality model. Br J Radiol. 1996;69(825):839–846
  46. Mackie TR, Scrimger JW, Battista JJ. A convolution method of calculating dose for 15-MV x rays. Med Phys. 1985;12(2):188–196
  47. Brahme A. Individualizing cancer treatment: biological optimization models in treatment planning and delivery. Int J Radiat Oncol Biol Phys. 2001;49(2):327–337
  48. Källman P, gren A, Brahme A. Tumour and normal tissue responses to fractionated non-uniform dose dilivery. Int J Radiat Biol. 1992;62(2):249–262
  49. gren A. Quantification of the response of heterogeneous tumours and organized normal tissues to fractionated radiotherapy. In: Ph.D. Thesis. Sweden: Stockholm University; 1995;
  50. Gaghandi G, Bjohle J, Lax I, et al. Radiation pneumonitis after breast cancer irradiation: analysis of the complication probability using the relative seriality model. Int J Radiat Oncol Biol Physical. 2000;46(2):373–381
  51. Johansson S, Svensson H, Denekamp J. Dose response and lavency for radiation-induced fibrosis, edema, and neuropathy in breast cancer patients. Int J Radiat Oncol Biol Phys. 2002;52(5):1207–1219
  52. Okunieff P, Morgan D, Niemierko A, Suit HD. Radiation dose-response of human tumors. Int J Radiat Oncol Biol Phys. 1995;32(4):1227–1237
  53. Withers HR, Peters LJ, Taylor JM. Dose-response relationship for radiation therapy of subclinical disease. Int J Radiat Oncol Biol Phys. 1995;31(2):353–359
  54. Moiseenko V, Craig T, Bezjak A, Van Dyk J. Dose-volume analysis of lung complications in the radiation treatment of malignant thymoma: a retrospective review. Radiother Oncol. 2003;67(3):265–274
  55. Unnithan J, Macklis RM. Contralateral breast cancer risk. Radiother Oncol. 2001;60(3):239–246
  56. Storm HH, Jensen OM. R.sk of contralateral breast cancer in Denmark 1943–80. Br J Cancer. 1986;54(3):483–492
  57. Costa Ferreira B. Biological optimization of angle of incidence and intensity modulation in breast and cervix cancer radiation therapy. In: Ph.D. Thesis. Sweden: Stockholm University; 2004;
  58. Jeraj R, Keall PJ, Siebers JV. The effect of dose calculation accuracy on inverse treatment planning. Phys Med Biol. 2002;47(3):391–407
  59. Scholz C, Nill S, Oelfke U. Comparison of IMRT optimization based on a pencil beam and a superposition algorithm. Med Phys. 2003;30(7):1909–1913
  60. Brahme A. Biologically optimized 3-dimensional in vivo predictive assay-based radiation therapy using positron emission tomography-computerized tomography imaging. Acta Oncol. 2003;42(2):123–136
  61. Svensson R, Lind B, Brahme A. Beam characteristics and clinical possibilities of a new compact treatment unit design combining narrow pencil beam scanning and segmental multileaf collimation. Med Phys. 1998;25(12):2358–2369
  62. Mackie TR, Holmes T, Swerdloff S, et al. Tomotherapy: a new concept for the delivery of dynamic conformal radiotherapy. Med Phys. 1993;20(6):1709–1719

PII: S1120-1797(06)80005-0

doi: 10.1016/S1120-1797(06)80005-0

Physica Medica: European Journal of Medical Physics
Volume 22, Issue 1 , Pages 3-15 , January 2006

Article Tools