Physica Medica: European Journal of Medical Physics
Volume 23, Issue 3 , Pages 100-106 , December 2007

On the parameter describing the generalised equivalent uniform dose (gEUD) for tumours

  • Åste Søvik

      Affiliations

    • Department of Medical Physics, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    • Department of Physics, University of Oslo, 0316 Oslo, Norway
    • ,
  • Jostein Ovrum

      Affiliations

    • Department of Physics, University of Oslo, 0316 Oslo, Norway
    • Department of Radiation Biology, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    • ,
  • Dag Rune Olsen

      Affiliations

    • Department of Physics, University of Oslo, 0316 Oslo, Norway
    • Department of Radiation Biology, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    • ,
  • Eirik Malinen

      Affiliations

    • Department of Medical Physics, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    • Department of Physics, University of Oslo, 0316 Oslo, Norway
    • Corresponding Author InformationCorresponding author. Department of Medical Physics, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway.

Received 26 July 2007 ,Revised 16 September 2007 ,Accepted 19 September 2007.

References 

  1. Intensity Modulated Radiation Therapy Collaborative Work Group . Intensity-modulated radiotherapy: current status and issues of interest. Int J Radiat Oncol Biol Phys. 2001;51:880–914
  2. Niemierko A. Reporting and analyzing dose distributions: a concept of equivalent uniform dose. Med Phys. 1997;24:103–110
  3. Niemierko A. A generalized concept of equivalent uniform dose (EUD). Med Phys. 1999;26:1100
  4. Wu Q, Mohan R, Niemierko A, Schmidt-Ullrich R. Optimization of intensity-modulated radiotherapy plans based on the equivalent uniform dose. Int J Radiat Oncol Biol Phys. 2002;52:224–235
  5. Thieke C, Bortfeld T, Niemierko A, Nill S. From physical dose constraints to equivalent uniform dose constraints in inverse radiotherapy planning. Med Phys. 2003;30:2332–2339
  6. Olafsson A, Jeraj R, Wright SJ. Optimization of intensity-modulated radiation therapy with biological objectives. Phys Med Biol. 2005;50:5357–5379
  7. Nahum AE, Sanchez-Nieto B. Tumor control probability modelling: basic principles and applications in treatment planning. Physica Medica. 2001;XVII:13–23
  8. Ebert MA. Viability of the EUD and TCP concepts as reliable dose indicators. Phys Med Biol. 2000;45:441–457
  9. Cranmer-Sargison G, Zavgorodni S. EUD-based radiotherapy treatment plan evaluation: incorporating physical and Monte Carlo statistical dose uncertainties. Phys Med Biol. 2005;50:4097–4109
  10. Tome WA, Fowler JF. On cold spots in tumor subvolumes. Med Phys. 2002;29:1590–1598
  11. Wang JZ, Guerrero M, Li XA. How low is the alpha/beta ratio for prostate cancer?. Int J Radiat Oncol Biol Phys. 2003;55:194–203
  12. Nahum AE, Movsas B, Horwitz EM, Stobbe CC, Chapman JD. Incorporating clinical measurements of hypoxia into tumor local control modeling of prostate cancer: implications for the alpha/beta ratio. Int J Radiat Oncol Biol Phys. 2003;57:391–401
  13. Bullen PS, Mitrinovic DS, Vasic PM. The power means. In:  Bullen PS,  Mitrinovic DS,  Vasic PM editor. Means and their inequalities. Dordrecht: D. Reidel Publishing Company; 1988;p. 132–214
  14. Bentzen SM, Ritter MA. The alpha/beta ratio for prostate cancer: what is it, really?. Radiother Oncol. 2005;76:1–3
  15. Valdagni R, Italia C, Montanaro P, Lanceni A, Lattuada P, Magnani T, et al. Is the alpha-beta ratio of prostate cancer really low? A prospective, non-randomized trial comparing standard and hyperfractionated conformal radiation therapy. Radiother Oncol. 2005;75:74–82
  16. Park CS, Kim Y, Lee N, Bucci KM, Quivey JM, Verhey LJ, et al. Method to account for dose fractionation in analysis of IMRT plans: modified equivalent uniform dose. Int J Radiat Oncol Biol Phys. 2005;62:925–932
  17. Chapet O, Thomas E, Kessler ML, Fraass BA, Ten Haken RK. Esophagus sparing with IMRT in lung tumor irradiation: an EUD-based optimization technique. Int J Radiat Oncol Biol Phys. 2005;63:179–187
  18. Tome WA, Fowler JF. On the inclusion of proliferation in tumour control probability calculations for inhomogeneously irradiated tumours. Phys Med Biol. 2003;48:N261–N268
  19. Kallman P, Lind BK, Brahme A. An algorithm for maximizing the probability of complication-free tumour control in radiation therapy. Phys Med Biol. 1992;37:871–890

PII: S1120-1797(07)00062-2

doi: 10.1016/j.ejmp.2007.09.001

Physica Medica: European Journal of Medical Physics
Volume 23, Issue 3 , Pages 100-106 , December 2007

Article Tools

* Image Usage & Resolution