Physica Medica: European Journal of Medical Physics
Volume 25, Issue 1 , Pages 1-11 , March 2009

State of the art and challenges of time-of-flight PET

Received 19 June 2008 ,Revised 1 October 2008 ,Accepted 5 October 2008.

References 

  1. Budinger TF. Instrumentation trends in nuclear medicine. Semin Nucl Med. 1977;7:285–297
  2. Budinger TF. Time-of-flight positron emission tomography: status relative to conventional PET. J Nucl Med. 1983;24:73–78
  3. Mullani NA, Markham J, Ter-Pogossian MM. Feasibility of time-of-flight reconstruction in positron emission tomography. J Nucl Med. 1980;21:1095–1097
  4. Gariod R, Allemand R, Carmoreche E, et al. The LETI Positron tomograph architecture and time of flight improvements. Proceeding of the Workshop on Time-of-Flight tomography. IEEE Publication: Washington University; 1982;p. 25-29
  5. Bendriem B, Soussaline F, Campagnolo R, Verrey B, Wajnberg P, Syrota A. A technique for the correction of scattered radiation in a PET system using Time-of-Flight information. J. Comput Assist Tomogr. 1986;10(2):287–295
  6. Ter-Pogossian MM, Ficke DC, Yamamoto M, et al. Super PETT I: a positron emission tomograph utilizing photon time-of-flight information. Trans Med Imaging. 1982;1:179–186
  7. Yamamoto M, Ficke DC, Ter-Pogossian MM. Experimental assessment of the gain achieved by the utilization of time-of-flight information in a positron emission tomograph (Super PETT I). IEEE Trans Med Imaging. 1982;1:187–192
  8. Wong WH, Mullani NA, Philippe EA, Hartz RK, Gould KL. Image improvement and design optimization of the Time-of-Flight PET. J Nucl Med. 1983;24:52–60
  9. Wong WH, Mullani NA, Philippe EA, Hartz RK, Bristow D, Yerian K, et al. Performance characteristics of the University of Texas TOFPET-I PET camera. J Nucl Med. 1984;25:46–47
  10. Tomitani T. Image reconstruction and noise evaluation in photon time-of-flight assisted positron emission tomography. IEEE Trans Nucl Sci. 1981;28:4582–4588
  11. Yamamoto M, Nohara N, Tanaka E, Tomitani T, Murayama H, Sato N, et al. Time-of-flight positron imaging and the resolution improvement by an iterative method. IEEE Trans Nucl Sci. 1989;36:998–1002
  12. Lewellen TK, Bice AN, Harrison RL, Pencke MD, Link JM. Performance measurements of the SP3000/UW time-of-flight positron emission tomograph. IEEE Trans Nucl Sci. 1988;35(1):665–669
  13. Allemand R, Gresset C, Vacher J. Potential advantages of a cesium fluoride scintillator for a time of flight positron camera. J Nucl Med. 1980;21:153–155
  14. Laval M, Moszynski M, Allemand R, Cormoreche E, Guinet P, Odru R, et al. Barium fluoride—Inorganic scintillator for subnanosecond timing. Nucl Inst Methods. 1983;206:169–176
  15. Ishii K, Orihara H, Matsuzawa T, Binkley DM, Nutt R. High resolution time-of-flight positron emission tomograph. Rev Sci Instr. 1990;61(12):3755–3762
  16. Soussaline S, Comar D, Allemand R, Campagnolo R, Laval M, Vacher J, et al. New developments in positron emission tomography instrumentation using the time-of-flight information. In:  Gretz T editors. The metabolism of the human brain studied with positron emission tomography. New York: Raven Press; 1985;p. 1–11
  17. Lewellen TK. Time-of-flight PET. Semin Nucl Med. 1998;28(3):268–275
  18. Weber MJ, Monchamp RR. Luminescence of Bi4Ge3O12—spectral and decay properties. J Appl Phys. 1973;44:5495–5499
  19. Melcher CL, Schweitzer JS. Cerium-doped lutetium orthosilicate: a fast, efficient new scintillator. IEEE Trans Nucl Sci. 1992;39:502–505
  20. Wienhard K, Schmand M, Casey ME, Baker K, Bao J, Eriksson L, et al. The ECAT HRRT: Performance and first clinical application of the new high resolution research tomograph. IEEE Trans Nucl Sci. 2002;49(1):104–110
  21. Herzog H, Tellmann L, Hocke C, Pietrzyk U, Casey ME, Kuwert T. NEMA NU2-2001 guided performance evaluation of four Siemens ECAT PET scanners. IEEE Trans Nucl Sci. 2004;51(5):2662–2669
  22. Moses WW, Derenzo SE. Prospects for time-of-flight PET using LSO scintillator. IEEE Trans Nucl Sci. 1999;46(3):783–788
  23. Conti M, Bendriem B, Casey M, Chen M, Kehren F, Michel C, et al. Implementation of time-of-flight on CPS HiRez PET scanner. 2004 IEEE Nuclear Science Symposium Conference Record, Rome, Italy, October 16–22, 2004.
  24. Conti M, Bendriem B, Casey M, Chen M, Kehren F, Michel C, et al. First experimental results of Time-Of-Flight reconstruction on an LSO PET scanner. Phys Med Biol. 2005;50:4507–4526
  25. van Loef E, Dorenbos P, van Eijk CWE, Kramer KW, Gudel HU. High-energy-resolution scintillator: Ce3+ activated LaBr3. Appl Phys Lett. 2005;79:1573–1573
  26. Surti S, Karp JS, Muehllehner G, Raby PS. Investigation of lanthanum scintillators for 3-D PET. IEEE Trans Nucl Sci. 2003;50(3):348–354
  27. Karp JS, Kuhn A, Perkins AE, Surti S, Werner ME, Daube-Witherspoon ME, et al. Characterization of a time-of-flight PET scanner based on lanthanum bromide. 2005 IEEE Nuclear Science Symposium Conference Record, Puerto Rico, October 23–29, 2005.
  28. Kyba CCM, Wiener RI, Newcomer FM, Van Berg R, Dressnandt N, Karp JS. Timing measurements from a TOF-PET scanner using local PMT triggering. IEEE 2007 Nuclear Science Symposium Conference Record, Honolulu, Hawaii, October 27–November 3, 2007.
  29. Surti S, Kuhn A, Werner ME, Perkins AE, Kolthammer J, Karp JS. Performance of Philips Gemini TF PET/CT scanner with special consideration for its time-of-flight imaging capabilities. J Nucl Med. 2007;48(3):471–480
  30. Conti M, Townsend DW, Casey ME, Lois C, Jacoby BW, Long MJ, et al. Assessment of the clinical potential of a time-of-flight PET/CT scanner. 2008 SNM Annual Meeting Proceedings, New Orleans, Louisiana, June 14–18, 2008.
  31. Moses WW. Time of flight in PET revisited. IEEE Trans Nucl Sci. 2003;50(5):1325–1330
  32. Muehllehner G, Karp JS. Positron emission tomography. Phys Med Biol. 2006;51:R117–R137
  33. Lewellen TK, Harrison RL, Bice AN. An experimental evaluation of the effect of time-of-flight information in image reconstruction for the Scanditronix/PETT electronics SP-3000 positron emission tomograph - preliminary results. IEEE Trans Nucl Sci. 1989;36:1095–1099
  34. Snyder DL, Thomas LJ, Ter-Pogossian MM. A mathematical model for positron emission tomography systems having time-of-flight measurements. IEEE Trans Nucl Sci. 1981;28(3):3575–3583
  35. Strother SC, Casey ME, Hoffman EJ. Measuring PET scanner sensitivity: relating count rates to image signal-to-noise ratios using noise equivalent counts. IEEE Trans Nucl Sci. 1990;37(2):783–788
  36. Conti M. Effect of random reduction on signal-to-noise-ratio in TOF PET. IEEE Trans Nucl Sci. 2006;53(3):1188–1193
  37. Aykac M, Bauer F, Williams CW, Loope M, Schmand M. Timing performance of Hi-Rez detector for time-of-flight (TOF) PET. IEEE Trans Nucl Sci. 2006;53(3):1184–1189
  38. Moses WW, Ullisch M. Factors influencing timing resolution in a commercial LSO PET camera. IEEE Trans Nucl Sci. 2006;53(1):78–85
  39. Szczesniak T, Moszynski M, Swiderski L, Nassalski A, Lavoute P, Kapusta M. Fast photomultipliers for TOF PET. IEEE 2007 Nuclear Science Symposium Conference Record, Honolulu, Hawaii, October 27–November 3, 2007.
  40. Hyman LG. Time resolution of photomultiplier systems. Rev Sci Instr. 1965;36(3):193–196
  41. Moszynski M, Bengtson B. Status of timing with plastic scintillation detectors. Nucl Instr Methods. 1979;158:1–31
  42. Szczesniak T, Moszynski M, Nassalski A, Lavoute P, Dehaine AG. A further study of timing with LSO on XP20D0 for TOF PET. IEEE Trans Nucl Sci. 2007;54(5):1464–1473
  43. Nassalski A, Kapusta M, Batsch T, Wolski D, Moeckel D, Enghardt W, et al. Comparative study of scintillators for PET/CT detectors. IEEE Trans Nucl Sci. 2007;54(1):3–10
  44. Glodo J, Moses WW, Higgins WM, van Loef EV, Wong P, Derenzo SE, et al. Effects of Ce Concentration on scintillation properties of LaBr3:Ce. IEEE Trans Nucl Sci. 2005;52(5):1805–1808
  45. Shao Y. A new timing model for calculating the intrinsic timing resolution of a scintillator detector. Phys Med Biol. 2007;52:1103–1117
  46. Dorenbos P. Light output and energy resolution of Ce3+-doped scintillators. Nucl Instr Methods A. 2002;486:208–213
  47. Kapusta M, Szupryczynski P, Melcher CL, Moszynski M, Balcerzyk M, Carey AA, et al. Non-proportionality and thermoluminescence of LSO:Ce. IEEE Trans Nucl Sci. 2005;52(4):1098–1104
  48. Prelude420 Data Sheet, Saint-Gobain Crystals; 2007.
  49. Pidol L, Kahn-Harari A, Viana B, Virey E, Ferrand B, Dorenbos P, et al. High efficiency of lutetium silicate scintillators, Ce-doped LPS, and LYSO crystals. IEEE Trans Nucl Sci. 2004;51(3):1084–1087
  50. Lecoq P, Korzhik M. New inorganic scintillation materials development for medical imaging. IEEE Trans Nucl Sci. 2002;49(4):1651–1654
  51. Moszynski M, Wolski D, Ludziejewski T, Kapusta M, Lempicki A, Brecher C, et al. Properties of the new LuAP:Ce scintillator. Nucl Instr Methods A. 1997;385:123–131
  52. Weber S, Christ D, Kurzeja M, Engels R, Kemmerling G, Halling H. Comparison of LuYAP, LSO, BGO as scintillators for high resolution PET detectors. IEEE Trans Nucl Sci. 2003;50(5):1370–1372
  53. Korzhik M, Federov A, Annenkov A, Borissevitch A, Dossovitski A, Missevitch O, et al. Development of scintillator materials for PET scanners. Nucl Instr Methods A. 2007;571:122–125
  54. Nikl M, Ogino H, Krasnikov A, Beitleroval A, Yoshikawa A, Fukuda T. Photo- and radioluminescence of Pr-doped Lu3Al5O12 single crystal. Phys Stat Sol A. 2005;202(1):R4–R6
  55. Ogino H, Yoshikawa A, Nikl M, Pejchalm J, Fukuda T. Growth and luminescence properties of Pr-doped Lu3(Ga,Al)5O12 single crystals. Jpn J Appl Phys. 2007;46:3514–3517
  56. Kamada K, Tsutsumi K, Usuki Y, Yanagida T, Sato M, Ogino H, et al. Scintillation properties of 2-inch-diameter Pr:Lu3Al5O12 single crystal. IEEE 2007 Nuclear Science Symposium Conference Record, Hunolulu, Hawaii, October 27–November 3, 2007.
  57. Pr:LuAG data sheet, Furukawa Co. Ltd., http://www.furukawakk.co.jp, 2007.
  58. Conti M, Eriksson L, Rothfuss H, Melcher C. Comparing fast scintillators with TOF PET potentiality. 2008 Symposium on Radiation Measurements and Applications, Berkeley, California, USA, June 2–5, 2008, to be published in IEEE Trans Nucl Sci, 2009.
  59. van Loef EVD, Dorenbos P, van Eijk CWE, Krämer K, Güdel HU. Scintillation properties of LaCl3:Ce3+ crystals: fast, efficient, and high-energy resolution scintillators. IEEE Trans Nucl Sci. 2001;48(3):341–345
  60. Brillance 350 Data Sheet, Saint-Gobain Crystals, http://www.detectors.saint-gobain.com/, 2007.
  61. Shah KS, Glodo J, Klugerman M, Moses WW, Derenzo SE, Weber MJ. LaBr3:Ce scintillators for gamma-ray spectroscopy. IEEE Trans Nucl Sci. 2003;50(6):2410–2413
  62. Brillance 380 Data Sheet, Saint-Gobain Crystals, http://www.detectors.saint-gobain.com/, 2007.
  63. Shah KS, Glodo J, Klugerman M, Higgins W, Gupta T, Wong P, et al. LuI3:Ce—a new scintillator for gamma ray spectroscopy. IEEE Trans Nucl Sci. 2004;51(5):2302–2305
  64. Glodo J, Shah KS, Klugerman M, Wong P, Higgins W, Dorenbos P. Scintillation properties of LuI3:Ce. Nucl Instr Methods A. 2005;537:279–281
  65. Birowosuto MD, Dorenbos P, van Eijk CWE, Krämer KW, Güdel HU. Scintillation properties of LuI3:Ce3+-high light yield scintillators. IEEE Trans Nucl Sci. 2005;52(4):1114–1118
  66. Birowosuto MD, Dorenbos P, de Haas JTM, van Eijk CWE, Krämer KW, Güdel HU. Optical properties and luminescence quenching of LuI3:Ce3+. J Luminesc. 2006;118:308–316
  67. National Institute of Standards and Technology, Reference data table for X-ray interactions, http://physics.nist.gov/PhysRefData/.
  68. Shepp LA, Vardi Y. Maximum likelihood reconstruction for emission tomography. IEEE Trans Med Imaging. 1982;1:113–122
  69. Snyder DL, Politte DG. Image reconstruction from list-mode data in an emission tomography system having time-of-flight measurements. IEEE Trans Nucl Sci. 1983;20:1843–1849
  70. Politte DG. Image improvements in positron-emission tomography due to measuring differential time-of-flight and using maximum-likelihood estimation. IEEE Trans Nucl Sci. 1990;37:737–742
  71. Wang W, Hu Z, Gualtieri EE, Parma MJ, Walsh ES, Sebok D, et al. Systematic and distributed time-of-flight list mode PET reconstruction. 2006 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, San Diego, California, October 29–November 4, 2006.
  72. Watson CC. An improved kernel for analytical Time-of-Flight PET reconstruction. 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, Honolulu, Hawaii, October 27–November 3, 2007.
  73. Watson CC. Signal-to-noise ratio equalized filtered back-projection for emission tomography. 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, Honolulu, Hawaii, October 27–November 3, 2007.
  74. Popescu LM. Iterative image reconstruction using geometrically ordered subsets with listmode data. 2004 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, Rome, Italy, October 16–22, 2004.
  75. Popescu LM, Lewitt R. Raytracing through a grid of blobs. 2004 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, Rome, Italy, October 16–22, 2004.
  76. Groiselle CJ, Glick SJ. 3D PET list-mode iterative reconstruction using time-of-flight information. 2004 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, Rome, Italy, October 16–22, 2004.
  77. Defrise M, Casey ME, Michel C, Conti M. Exact and approximate rebinning methods for time-of-flight PET. Phys Med Biol. 2005;50:2749–2763
  78. Vandenberghe S, Daube-Witherspoon ME, Lewitt RM, Karp JS. Fast reconstruction of 3D time-of-flight PET data by axial rebinning and transverse mashing. Phys Med Biol. 2006;51:1603–1621
  79. Watson CC. Extension of single scatter simulation to scatter correction of time-of-flight PET. IEEE Trans Nucl Sci. 2007;54(5):1679–1686
  80. Werner ME, Surti S, Karp JS. Implementation and evaluation of a 3D PET single scatter simulation with TOF modeling. 2006 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, San Diego, California, October 29–November 4, 2006.
  81. Iatrou M, Manjeshwar RM, Stearns CW. Comparison of two 3D implementations of TOF scatter estimation in 3D PET. 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, Honolulu, Hawaii, October 27–November 3, 2007.
  82. Surti S, Karp JS, Popescu LM, Daube-Witherspoon ME, Werner M. Investigation of time-of-flight benefit for fully 3-D PET. IEEE Trans Med Imaging. 2006;25(5):529–538
  83. Karp JS, Surti S, Daube-Witherspoon ME, Muehllehner G. Benefit of time-of-flight in PET: experimental and clinical results. J Nucl Med. 2008;49(3):462–470
  84. Surti S, Karp JS. Design considerations for a limited-angle, dedicated breast, TOF PET scanner. 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, Honolulu, Hawaii, October 27–November 3, 2007.
  85. Shakirin G, Crespo P, Braess H, Enghardt W. Influence of the time of flight information on the reconstruction of in-beam PET data. 2007 IEEE Nuclear Science Symposium and Medical Imaging ConferenceRecord, Honolulu, Hawaii, October 27–November 3, 2007.

PII: S1120-1797(08)00097-5

doi: 10.1016/j.ejmp.2008.10.001

Physica Medica: European Journal of Medical Physics
Volume 25, Issue 1 , Pages 1-11 , March 2009